The same research proposal was submitted to 24 district health authority (DHA) research ethics committees in different parts of the country. The objective was to obtain permission for a multi-centre research project. The study of neonatal care in different types of unit (regional, subregional and district), required that four health authorities were approached in each of six widely separated health regions in England. Data were collected and compared concerning aspects of processing, including application forms, information required, timing and decision-making. The (...) key finding was that ethics committees received and processed the applications variably, reflecting individual factors and local problems. To improve consensus and facilitate multicentre studies, standard forms and instructions are suggested and the establishment of a national committee or advisory group advocated. (shrink)

Many biosystems are complex mixtures of disparate biofluids. To study contact and transport phenomena in these mixtures, one has to apply much information on the biofluids which are components of the mixtures. A lot of the corresponding data can be extracted by means of experiments. However, it is not always easy to obtain experimental results on rather deep physical characteristics of biofluids, especially if the bioparticles are complicated systems and the fluid coexists in the mixture with a large number of (...) other fluids. In these cases, the necessary data can, in principle, be extracted from those results which are easier to obtain experimentally. The present work proposes a method to evaluate the biofluid equilibrium pressure and electrochemical potential from common experimental values of the fluid concentration and absolute temperature as well as the fluid-particle mass, volume and spin. In so doing, the nonzero values of the particle volume are accounted for. The procedure is illustrated with a numerical example on the fluid of red blood cells (or erythrocytes) in human blood. The pressure values obtained are 49.1 and 38.8 micropascals for men and women respectively whereas the electrochemical-potential values are –2.124 and –2.130 electronvolts for men and women respectively. (shrink)

From 1956, when the complex ultrastructure of meiotic chromosomes was discovered, 1 until 1985, when the isolation of meiotic chromosome cores was reported, knowledge of the molecular structure of the meiotic chromosome was at best a dream. The dissection of meiotic chromosome structures has become a realistic challenge through the arrival of isolated symptonemal complexes (SCs), monoclonal and polyclonal antibodies against SCs, the possibility for screening expression libraries for genes that encode SC proteins, the isolation of SC‐associated DNA, and the (...) development of techniques for the in situ recognition of DNA sequences in the context of the meiotic chromosome structure. (shrink)

The appearance of Nan Dunbar's important commentary onBirdsis to be welcomed. Inevitably, however, such a volume requiresaddenda et corrigenda; and already the author must be collecting material for a second edition. Here is somepabulum. On the passage cited, Dunbar comments, ‘The difficulties of this sentence stem from uncertainty over (a) the form and sense of the main verb … and (b) the point of χαραδρι⋯ν μιμο⋯μενος and its connection with what precedes …’.

_341_ _Objectives: _In patients with multivessel disease both the detection of the culprit lesion and the exact allocation are important preconditions for sufficient treatment and improved outcome. In a vessel based approach the combination of quantitative coronary angiography and fractional flow reserve measured by a pressure wire should be advantageous compared to myocardial SPECT, as morphological and functional information is delivered simultaneously. Therefore our aim was to evaluate MS in the detection and allocation of hemodynamically significant stenoses obtained by the (...) combined gold standard QCA plus FFR in patients with multivessel disease. _Methods: _FFR and QCA of 95 vessels in 80 patients have been evaluated. Hemodynamically significant target lesions were defined as intermediate stenoses between 50 and 75% with an FFR. (shrink)

Bacteria have evolved advanced strategies for surviving during nutritional stress, including expression of specialized enzyme systems that allow them to grow on unusual nutrient sources. Inorganic phosphate (Pi) is limiting in most ecosystems, hence organisms have developed a sophisticated, enzymatic machinery known as carbon‐phosphorus (C‐P) lyase, allowing them to extract phosphate from a wide range of phosphonate compounds. These are characterized by a stable covalent bond between carbon and phosphorus making them very hard to break down. Despite the challenges involved (...) in both synthesizing and catabolizing phosphonates, they are widespread in nature. The enzymes required for the bacterial C‐P lyase pathway have been identified and for the most part structurally characterized. Nevertheless, the mechanistic principles governing breakdown of phosphonate compounds remain enigmatic. In this review, an overview of the C‐P lyase pathway is provided and structural aspects of the involved enzyme complexes are discussed with a special emphasis on the role of ATP‐binding cassette (ABC) proteins. (shrink)

We show that the analysis of Keisler’s order can be localized to the study of φ-types. Specifically, if is a regular ultrafilter on λ such that and M is a model whose theory is countable, then is λ+-saturated iff it realizes all φ-types of size λ.

Organized by Richard Kearney and Joseph S. O’Leary, the 1979 Colloquium Heidegger et la question de Dieu was of critical importance for the development of phenomenology of religion in France. This special issue introduces the event and its ensuing publication to the English-speaking world. The editors’ historical and thematic contextualizing essay is followed by contributions from six leading philosophers. Richard Kearney sets the stage by updating his original foreword, while Jean-Yves Lacoste presents the central moments in the history of Heidegger’s (...) complicated relationship to Christian thinking. Paul Ricoeur’s “Introductory Note” delivers a well-known challenge to Heidegger in a piece whose brevity belies its impact. Finally, three participants of the 1979 Colloquium, Joseph S. O’Leary, Jean Greisch, and Jean-Luc Marion, reflect back on the significance of this event and its role in developing their own groundbreaking work. The special issue closes with a brief reflection on where we find ourselves in philosophy today. (shrink)